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Benchtop Data.

Measurement of droplet volume with and without Nanodropper

Nanodropper decreases the volume of eyedrops of nine different ophthalmic medications. (A) Visual comparison of drops produced from the original bottle (left) and with Nanodropper attached (right). (B) Mean volume of current eyedrops and Nanodropper-mediated microdrops collected for nine different drugs. n = 4-97 independent mass measurements of 1-12 drops. Two-way ANOVA with Sidak’s post-hoc tests; interaction of Drug x Dispenser, F8, 540 = 131, P<0.0001; main effect of drug, F8, 540 = 693.7, P<0.0001; main effect of dispenser, F1, 540 = 12866, P<0.0001. (C) Mean volume of current eyedrops and Nanodropper-mediated microdrops from all nine medications combined. n = 154-404 independent mass measurements of 1-12 drops. Unpaired t-test; t(556) = 43.66, P<0.0001. (D) Mean volume of current eyedrops and Nanodropper-mediated microdrops of the six ocular hypotensive prescription medications used to treat glaucoma: Lumigan, Timolol, Alphagan P, Combigan, Cosopt, and Azopt. n = 103-282 independent mass measurements of 1-10 drops. Unpaired t-test; t(383) = 33.8, P<0.0001. (E) Mean volume of current eyedrops and Nanodropper-mediated microdrops of the five tested medications that are formulated as solutions: Lumigan, Timolol, Alphagan P, Combigan, and Cosopt. n = 70-185 independent mass measurements of 1-10 drops. Unpaired t-test; t(253) = 22.7, P<0.0001. (F) Mean volume of current eyedrops and Nanodropper-mediated microdrops of the two tested medications that are formulated as suspensions: Azopt and Pred Forte. n = 47-133 independent mass measurements of 2-12 drops. Unpaired t-test; t(178) = 49.69, P<0.0001. (G) Mean volume of current eyedrops and Nanodropper-mediated microdrops of the two tested medications that are formulated as emulsions: Systane and Systane Complete. n = 37-86 independent mass measurements of 3-11 drops. Unpaired t-test; t(121) = 35.25, P<0.0001. Error bars, SEM. ****P<0.0001.

References: (A) Nanodropper, Inc. (B)-(G) St. Peter et al., 2021, unpublished.

Benchtop data collected in collaboration with University of Colorado Anschutz Medical Campus, Department of Ophthalmology.

Clinical data coming soon.

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